منابع مشابه
Morphogenesis of the mammalian blastocyst.
The first 4 days of mouse pre-implantation development are characterized by a period of segmentation, including morphogenetic events that are required for the divergence of embryonic and extra-embryonic lineages. These extra-embryonic tissues are essential for the implantation into the maternal uterus and for the development of the foetus. In this review, we first discuss data showing unambiguo...
متن کاملTheoretical exploration of blastocyst morphogenesis.
A theoretical exploration of cell distribution on the mouse blastocyst is conducted. A model ball of cells represents the morula which develops into a 32-cell model blastocyst that is enclosed in a spherical surface with a hemispherical cavity at one end. In the combinatorial analysis it is assumed that each cell of the 2-cell embryo forms 16 cells in the blastocyst and that these 16 cells touc...
متن کاملCell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis.
Cell adhesion plays a critical role in the differentiation of the trophectoderm epithelium and the morphogenesis of the blastocyst. In the mouse embryo, E-cadherin mediated adhesion initiates at compaction at the 8-cell stage, regulated post-translationally via protein kinase C and other signalling molecules. E-cadherin adhesion organises epithelial polarisation of blastomeres at compaction. Su...
متن کاملCell death in the mammalian blastocyst.
Cell death is a widespread feature in the blastocysts of many mammals. Isolated cells in both the inner cell mass and the trophectoderm undergo cell death. These dying cells appear morphologically to be undergoing apoptosis. In mouse blastocysts, a wave of cell death is seen in vivo, suggesting that it plays an important role in normal development. However, cell death is increased under subopti...
متن کاملTransforming growth factor-beta-related signaling in blastocyst morphogenesis
permissive to ES cell derivation compared to others. Second, when generating host/ES cell chimeras, certainmouse strain combinations are significantlymore successful than others.Wepropose that differences in the responsiveness to certain developmental cues may influence the timing or manner of lineage specification, thus causing inter-strain variance. To test this, we studymouse strains (129 Sv...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2008
ISSN: 0303-7207
DOI: 10.1016/j.mce.2007.11.004